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…showed last 75 words of 605 total…the injections, preferably after the baby is six weeks old; and the injections may improve pms, depression, and other symptoms from endometriosis. The disadvantages of the Depo-Provera injections are as follows: irregular periods; weight gain; they may lower estrogen level and cause bone loss; rare allergic reactions; and the injections will not protect an individual from HIV or other infections. Injections can be given to you by your clinician, health department, or family planning clinic.